Ob peb yam tseem ceeb cuam tshuam rau cov dej tuav ntawm Hydroxypropyl Methylcellulose
Hydroxypropyl Methylcellulose (HPMC) yog cov khoom siv polymer hauv ntau lub lag luam, suav nrog kev tsim kho, tshuaj, khoom noj, thiab kev saib xyuas tus kheej.Ib qho ntawm nws cov khoom tseem ceeb yog kev tuav dej, uas yog hais txog lub peev xwm ntawm HPMC khaws cov dej hauv cov qauv lossis cov khoom siv.Kev tuav dej yog qhov tseem ceeb hauv cov ntawv thov uas tswj cov dej noo, viscosity, thiab stability yog qhov tseem ceeb.Hauv tsab xov xwm no, peb yuav tshawb txog ntau yam tseem ceeb uas cuam tshuam rau kev tuav dej ntawm HPMC thiab sib tham txog lawv qhov tseem ceeb hauv kev lag luam sib txawv.Kev nkag siab txog cov xwm txheej no tuaj yeem pab cov kws tshawb fawb thiab cov tuam txhab tsim kho cov qauv tsim thiab txhim kho kev ua haujlwm ntawm HPMC-based cov khoom.
Molecular Luj ntawm HPMC
Qhov hnyav molecular ntawm HPMC yog ib qho tseem ceeb uas cuam tshuam rau nws lub peev xwm tuav dej.Lub cev hnyav dua molecular HPMC polymers zoo li muaj peev xwm tuav dej ntau dua piv rau qhov hnyav dua molecular.Qhov no yog vim qhov hnyav dua molecular HPMC muaj cov hlua polymer ntev dua, uas muaj ntau qhov chaw rau cov dej molecules los cuam tshuam thiab tsim cov hydrogen bonds.Yog li ntawd, cov hydrated polymer chains swell thiab khaws dej zoo dua.Cov neeg tsim khoom tuaj yeem xaiv qhov hnyav molecular ntawm HPMC raws li qhov xav tau cov dej tuav cov khoom rau cov ntawv thov tshwj xeeb.
Degree of Hloov (DS)
Qib ntawm kev hloov pauv yog hais txog qhov twg ntawm hydroxypropyl thiab methoxy hloov pauv ntawm cellulose qaum ntawm HPMC.Nws cuam tshuam rau cov dej tuav cov yam ntxwv ntawm HPMC.Feem ntau, DS tus nqi siab dua ua rau muaj kev txhim kho cov dej tuav.Cov pab pawg hydroxypropyl thiab methoxy nce hydrophilicity ntawm cov polymer, tso cai rau nws nqus thiab khaws dej ntau dua.Tus nqi DS tuaj yeem hloov kho thaum lub sijhawm sib txuas ntawm HPMC kom ua tiav cov dej khaws cia rau qhov sib txawv.
Concentration ntawm HPMC hauv Formulation
Qhov concentration ntawm HPMC nyob rau hauv ib tug formulation ncaj qha cuam tshuam rau nws cov dej tuav lub peev xwm.Raws li qhov concentration ntawm HPMC nce, muaj qhov sib npaug ntawm cov dej khaws cia.Qhov no yog vim tias muaj ntau dua ntawm HPMC muab cov chaw sib txuas ntau dua rau cov dej molecules, ua rau kev txhim kho dej thiab muaj peev xwm tuav dej.Txawm li cas los xij, nws yog ib qho tseem ceeb uas yuav tsum nco ntsoov tias qhov siab ntawm HPMC ntau dhau tuaj yeem ua rau muaj viscosity lossis gel tsim, uas tuaj yeem cuam tshuam tsis zoo rau daim ntawv thov thiab cov yam ntxwv ntawm kev tsim.
Kub thiab av noo
Kub thiab av noo yog ib puag ncig ib puag ncig uas tuaj yeem cuam tshuam cov dej tuav cov khoom ntawm HPMC-raws li formulations.Kev kub siab dua yuav ua rau kom cov evaporation ntawm cov dej los ntawm kev tsim, txo cov dej tuav.Hauv qhov sib piv, qhov ntsuas kub qis tuaj yeem txhawb nqa dej tuav los ntawm kev ua kom cov txheej txheem evaporation qeeb.Cov av noo kuj tseem ua lub luag haujlwm, vim tias cov av noo ntau dua tuaj yeem pab tswj cov dej noo hauv cov txheej txheem, txhim kho cov dej tuav.Nws yog ib qho tseem ceeb los txiav txim siab txog kev khiav hauj lwm thiab ib puag ncig ib puag ncig thaum tsim HPMC formulations los xyuas kom meej cov dej tuav tau zoo.
Kev sib cuam tshuam nrog lwm cov khoom xyaw
Lub xub ntiag ntawm lwm cov khoom xyaw hauv ib qho qauv tuaj yeem cuam tshuam rau cov dej tuav ntawm HPMC.Synergistic lossis antagonistic kev sib cuam tshuam tuaj yeem tshwm sim ntawm HPMC thiab lwm yam khoom ntxiv, cuam tshuam rau tag nrho cov dej tuav.Piv txwv li, qee cov ntsev los yog ions nyob rau hauv cov qauv yuav sib tw nrog HPMC rau cov dej molecules, txo nws cov peev xwm tuav dej.Ntawm qhov tod tes, koom nrog cov dej khaws cia ntxiv, xws li humectants lossis polyols, tuaj yeem txhim kho lub peev xwm tuav dej ntawm HPMC.Kev nkag siab txog kev sib raug zoo thiab kev sib cuam tshuam ntawm HPMC thiab lwm cov khoom xyaw yog qhov tseem ceeb rau kev tsim cov tshuab ua haujlwm zoo nrog cov khoom khaws dej zoo.
