Hydroxypropyl methylcellulose (HPMC) yog siv dav hauv cellulose ether paub txog nws cov khoom zoo heev.Nws yog dav siv nyob rau hauv ntau yam kev lag luam, nrog rau kev tsim kho, tshuaj, zaub mov thiab kev saib xyuas tus kheej.Hauv daim ntawv no, peb tsom mus rau cov nyhuv thickening ntawm HPMC thiab tshawb xyuas cov yam ntxwv uas cuam tshuam rau nws tus cwj pwm thickening.
Lub thickening mechanism ntawm HPMC yog:
Cov nyhuv thickening ntawm HPMC yog vim nws cov qauv molecular tshwj xeeb.Lub HPMC molecule muaj ib tug txha caj qaum ntawm cellulose chains nrog hydroxypropyl thiab methyl pawg txuas.Thaum HPMC dispersed nyob rau hauv dej los yog lwm yam kuab tshuaj, cov cellulose chains nqus dej thiab o, uas ua rau tsim ib tug 3D network qauv.Lub network no nkag mus rau cov kuab tshuaj thiab ua kom cov viscosity lossis dispersion ntawm cov tshuaj.
Cov yam ntxwv cuam tshuam cov nyhuv ntawm thickening:
Concentration: Lub concentration ntawm HPMC nyob rau hauv ib tug formulation plays ib tug tseem ceeb luag hauj lwm nyob rau hauv nws thickening nyhuv.Raws li qhov concentration nce, ntau HPMC molecules cuam tshuam, ua rau txhim kho viscosity thiab thickening.
Molecular Luj: Qhov hnyav molecular ntawm HPMC cuam tshuam rau nws cov khoom thickening.Siab dua molecular hnyav HPMC feem ntau pom muaj zog thickening nyhuv piv rau cov qib qis molecular phaus.
Kub: Qhov kub thiab txias tuaj yeem cuam tshuam rau tus cwj pwm thickening ntawm HPMC.. Feem ntau, nce qhov kub yuav txo qhov viscosity thiab thickening los ntawm HPMC tov.. Txawm li cas los xij, cov nyhuv no tuaj yeem sib txawv nyob ntawm qib tshwj xeeb ntawm HPMC.
Lub pH: Cov pH ntawm cov tshuaj kuj tuaj yeem cuam tshuam cov nyhuv thickening ntawm HPMC.. Qee qib ntawm HPMC tuaj yeem ua kom pom kev txhim kho thickening ntawm cov pH tshwj xeeb, thaum lwm tus tuaj yeem nkag siab ntau dua rau kev hloov pH.
Shear Rate: Tus nqi shear, los yog tus nqi ntawm cov kev daws teeb meem raug rau cov neeg kho tshuab kev nyuaj siab, tuaj yeem cuam tshuam tus cwj pwm thickening ntawm HPMC. shear tus nqi, xws li thaum stirring los yog daim ntawv thov, lub viscosity yuav txo tau vim shear rhuav cov qauv tsim los ntawm HPMC.
Daim ntawv thov ntawm Thickened HPMC:
Cov nyhuv thickening ntawm HPMC ua rau nws muaj txiaj ntsig zoo ntxiv hauv ntau daim ntawv thov.Qee cov ntawv thov siv xws li:
Kev tsim kho: HPMC yog siv rau hauv cov ntaub ntawv cemented xws li mortar thiab pobzeb adhesives los txhim kho lawv cov kev ua haujlwm, dej tuav thiab sag kuj.
Pharmaceuticals: HPMC yog ua hauj lwm ua ib tug thickener nyob rau hauv lub qhov ncauj ncua kev kawm ntawv, ophthalmic kev daws teeb meem thiab tshuaj pleev gels, muab qhov xav tau sib xws thiab txhim kho kev xa tshuaj.
Khoom noj khoom haus & Dej haus: HPMC yog siv ntau yam khoom noj xws li kua ntses, hnav khaub ncaws thiab khoom qab zib los txhim kho kev ntxhib los mos, ruaj khov thiab lub qhov ncauj.
Kev Kho Tus Kheej thiab Tshuaj pleev ib ce: HPMC pom cov ntawv thov hauv cov khoom siv tu tus kheej, suav nrog cov tshuaj pleev ib ce, tshuaj pleev thiab cov tshuaj tu plaub hau, ua cov thickener, stabilizer thiab cov neeg ua yeeb yaj kiab.
Hydroxypropyl methylcellulose (HPMC) nthuav tawm cov khoom hnyav hnyav vim nws cov qauv molecular tshwj xeeb thiab kev cuam tshuam nrog dej.Kev nkag siab txog cov yam ntxwv uas cuam tshuam rau cov nyhuv thickening ntawm HPMC, xws li concentration, molecular yuag, kub, pH, thiab shear rate, yog qhov tseem ceeb rau kev tsim cov khoom uas xav tau viscosity thiab sib xws.. ntau yam kev lag luam, muab kev ua tau zoo thiab txhim kho cov yam ntxwv ntawm cov khoom.
